Mode of action of colicins of types E1, E2, E3, and K.
نویسنده
چکیده
The effect of colicins on deoxyribonucleic acid and protein synthesis, and also their effect on the ability of T4 phage to replicate in Escherichia coli K-12, were studied. Colicins of type K inhibited deoxyribonucleic acid synthesis, protein synthesis, and phage growth. Among colicins of type E, there was an absolute correlation between mode of action and subdivision into types E(1), E(2), and E(3).
منابع مشابه
The TolA protein interacts with colicin E1 differently than with other group A colicins.
The 421-residue protein TolA is required for the translocation of group A colicins (colicins E1, E2, E3, A, K, and N) across the cell envelope of Escherichia coli. Mutations in TolA can render cells tolerant to these colicins and cause hypersensitivity to detergents and certain antibiotics, as well as a tendency to leak periplasmic proteins. TolA contains a long alpha-helical domain which conne...
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عنوان ژورنال:
- Journal of bacteriology
دوره 96 5 شماره
صفحات -
تاریخ انتشار 1968